Humoral Response Profiling Reveals Pathways to Prostate Cancer Progression
نویسندگان
چکیده
منابع مشابه
Humoral response profiling reveals pathways to prostate cancer progression.
There is considerable evidence for an association between prostate cancer development and inflammation, which results in autoantibody generation against tumor proteins. This immune system-driven amplification of the autoantibody response to intracellular antigens can serve as a sensitive tool to detect low abundance serum proteomic tumor markers for prostate cancer as well as provide insight in...
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Purpose:Human endogenous retroviruses (HERV) encode 8%of the human genome.WhileHERVsmay play a role in autoimmune and neoplastic disease, nomechanistic association has yet been established. We studied the expression and immunogenicity of a HERV-K GAG protein encoded on chromosome 22q11.23 in relation to the clinical course of prostate cancer. Experimental Design: In vitro expression of GAG-HERV...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2008
ISSN: 1535-9476
DOI: 10.1074/mcp.m700263-mcp200